Asymmetric synthesis of CF₂-functionalized aziridines by combined strong Brønsted acid catalysis

• Xing-Fa Tan,
• Fa-Guang Zhang and
• Jun-An Ma

Beilstein J. Org. Chem. 2020, 16, 638–644, doi:10.3762/bjoc.16.60

• ; difluoromethyl compounds; fluorinated diazo reagents; strong Brønsted acids; Introduction Chiral aziridines are prevalently found in natural products and artificially made bioactive molecules, thus receiving significant attention in the past decades [1][2][3][4][5][6]. Among them, the introduction of fluorine

Deoxygenative gem-difluoroolefination of carbonyl compounds with (chlorodifluoromethyl)trimethylsilane and triphenylphosphine

• Fei Wang,
• Lingchun Li,
• Chuanfa Ni and
• Jinbo Hu

Beilstein J. Org. Chem. 2014, 10, 344–351, doi:10.3762/bjoc.10.32

• , these relevant applications of 1,1-difluoroalkenes have led to many efforts to develop gem-difluoroolefination methods including β-elimination of functionalized difluoromethyl compounds, transition metal catalysed coupling reactions with gem-difluorovinylation reagents, and deoxygenative gem